Expression

ZSG determines DNA molecule quantity by directly counting the molecules in a sample.

cDNA molecules are individually visible.  There is no amplification, no need for fluorescent “interpretation.” Single-cell, single-molecule transcript analysis with splicing sensitivity should be especially useful for understanding cancer, immune, developing and nerve cells.

 

 

gene1
cDNA molecules directly visible. (The circle defines the binding region).

Background
In order to translate information stored in DNA into action, a cell makes a copy (RNA) of the short, relevant portion.  In any given cell, 10-30% of the genes are “expressed,” or actively giving instructions to the cell.  When the cell changes (illness), the amount of RNA produced by different genes changes to various degrees. Gene Expression tools measure this gene activity by measuring levels of RNA.

Application
The ZS Genetics' Gene Expression technology follows the Sequencing application.

Advantages
We can offer the Gene Expression performance of single molecule sensitivity on samples of a single cell.  We believe our technology will be more precise than than any existing technology.  Able to assess thousands of genes in a single assay, it will be less massively parallel than florescent microarray technologies, but far more sensitive and reproducible.  The measurement accuracy for single-cell assays will be superior to any competing technologies. 

Please e-mail inquiries@zsgenetics.com for more information.